Biomarker Analysis Resources

The NPRC biomarker analyses laboratories analyze nonhuman primate (NHP) and human samples in biomatrices for reproductive hormones, metabolic hormones, neurotransmitters and peptides, cytokines and vitamins. Several of the labs offer developmental work for new analytes by NIH funded investigators.

The laboratories offer several panels of analytes allowing for multiple compounds to be quantified in a single sample. Panels currently developed include multisteroid analyses, vitamin D metabolite panel, catecholamines (biogenic amines), inflammatory cytokines, and neurodegenerative disease panel. Custom panels may be requested.

Several platforms/technologies are available among the NPRC laboratories encompassing traditional to state-of-the-art methodologies. These include radiommunoassays (RIA) working with both alpha and beta particles, enzyme-linked immunoabsorbent assays (ELISA), chromatography separations, automated clinical platforms, high performance liquid chromatography (HPLC) linked with UV or electrochemical detection, and tandem tiple quadrupole mass spectrometry (LC/MS/MS).

The laboratories offer consultation in experimental design and collection/preparation of samples, development of new analyses in both individual analytes or multianalyte panels, evaluation of reproductive status, and other specialized methodology.

See the latest publications by members of the Biomarkers Working Group.