Other Key HIV/AIDS Publications (NPRC and Non-NPRC)


Baba TW, Jeong YS, Penninck D, Bronson R, Greene MF, Ruprecht RM.
Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques.
Science. 1995;267:1820-5.

Barouch DH, Santra S, Schmitz JE, Kuroda MJ, Fu TM, Wagner W, et al.
Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination.
Science. 2000;290(5491):486-92. Epub 2000/10/20. doi: 8915 [pii]. PubMed PMID: 11039923.

Daniel MD, Kirchhoff F, Czajak SC, Sehgal PK, Desrosiers RC.
Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene.
Science. 1992;228:1201-4.

Harouse JM, Gettie A, Tan RCH, Blanchard J, Cheng-Mayer C.
Distinct pathogenic sequela in rhesus macaques infected with CCR5 or CXCR4 utilizing SHIVs.
Science. 1999;284:816-8.

Hu S-L, Abrams K, Barber GN, Moran P, Zarling JM, Langlois AJ, et al.
Protection of macaques against SIV infection by subunit vaccines of SIV envelope glycoprotein gp160.
Science. 1992;255:456-9.

Johnson RP, Lifson JD, Czajak SC, Cole KS, Manson KH, Glickman R, et al.
Highly attenuated vaccine strains of simian immunodeficiency virus protect against vaginal challenge: inverse relationship of degree of protection with level of attenuation.
Journal of Virology. 1999;73(6):4952-61.

Letvin NL, Eaton KA, Aldrich WR, Sehgal PK, Blake BJ, Schlossman SF, et al.
Acquired immunodeficiency syndrome in a colony of macaque monkeys.
Proc Natl Acad Sci U S A. 1983;80(9):2718-22. Epub 1983/05/01. PubMed PMID: 6221343; PubMed Central PMCID: PMC393899.

Miller CJ, Li Q, Abel K, Kim EY, Ma ZM, Wietgrefe S, et al.
Propagation and dissemination of infection after vaginal transmission of simian immunodeficiency virus.
J Virol. 2005;79(14):9217-27. PubMed PMID: 15994816.

Paiardini M, Pandrea I, Apetrei C, Silvestri G.
Lessons learned from the natural hosts of HIV-related viruses.
Annu Rev Med. 2009;60:485-95. Epub 2009/07/28. doi: 10.1146/annurev.med.60.041807.123753. PubMed PMID: 19630581.

Schmitz JE, Kuroda MJ, Santra S, Sasseville VG, Simon MA, Lifton MA, et al.
Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes.
Science. 1999;283(5403):857-60. Epub 1999/02/05. PubMed PMID: 9933172.

Veazey RS, DeMaria M, Chalifoux LV, Shvetz DE, Pauley DR, Knight HL, et al.
Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection.
Science. 1998;280(5362):427-31. PubMed PMID: 9545219.

Veazey RS, DeMaria M, Chalifoux LV, Shvetz DE, Pauley DR, Knight HL, Rosenzweig M, Johnson RP, Desrosiers RC, Lackner AA.
Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection.
Science. 1998;280:427-31.

Wyand MS, Manson KH, Lackner AA, Desrosiers RC.
Resistance of neonatal monkeys to live attenuated vaccine strains of simian immunodeficiency virus.
Nature Medicine. 1997;3:32-6.

Zhang Z, Schuler T, Zupancic M, Wietgrefe S, Staskus KA, Reimann KA, et al.
Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells.
Science. 1999;286(5443):1353-7. PubMed PMID: 10558989.


Beaumier CM, Harris LD, Goldstein S, Klatt NR, Whitted S, McGinty J, et al.
CD4 downregulation by memory CD4+ T cells in vivo renders African green monkeys resistant to progressive SIVagm infection.
Nat Med. 2009;15(8):879-85. doi: 10.1038/nm.1970. PubMed PMID: 19525963; PubMed Central PMCID: PMCPMC2723181.

Hessell AJ, Poignard P, Hunter M, Hangartner L, Tehrani DM, Bleeker WK, et al.
Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques.
Nat Med. 2009;15(8):951-4. Epub 2009/06/16. doi: 10.1038/nm.1974. PubMed PMID: 19525965.

Johnson PR, Schnepp BC, Zhang J, Connell MJ, Greene SM, Yuste E, et al.
Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys.
Nat Med. 2009. Epub 2009/05/19. doi: nm.1967 [pii]10.1038/nm.1967. PubMed PMID: 19448633.

Li Q, Skinner PJ, Ha SJ, Duan L, Mattila TL, Hage A, et al.
Visualizing antigen-specific and infected cells in situ predicts outcomes in early viral infection.
Science. 2009;323(5922):1726-9. Epub 2009/03/28. doi: 323/5922/1726 [pii] 10.1126/science.1168676. PubMed PMID: 19325114; PubMed Central PMCID: PMC2753492.

Liu J, O'Brien KL, Lynch DM, Simmons NL, La Porte A, Riggs AM, et al.
Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys.
Nature. 2009;457(7225):87-91. Epub 2008/11/11. doi: nature07469 [pii] 10.1038/nature07469. PubMed PMID: 18997770; PubMed Central PMCID: PMC2614452.

Sacha JB, Giraldo-Vela JP, Buechler MB, Martins MA, Maness NJ, Chung C, et al.
Gag- and Nef-specific CD4+ T cells recognize and inhibit SIV replication in infected macrophages early after infection.
Proc Natl Acad Sci U S A. 2009;106(24):9791-6. Epub 2009/05/30. doi: 10.1073/pnas.0813106106. PubMed PMID: 19478057; PubMed Central PMCID: PMC2687996.

Velu V, Titanji K, Zhu B, Husain S, Pladevega A, Lai L, et al.
Enhancing SIV-specific immunity in vivo by PD-1 blockade.
Nature. 2009;458(7235):206-10. Epub 2008/12/17. doi: nature07662 [pii] 10.1038/nature07662. PubMed PMID: 19078956.


Barouch DH, O'Brien KL, Simmons NL, King SL, Abbink P, Maxfield LF, et al.
Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys.
Nat Med. 2010;16(3):319-23. doi: 10.1038/nm.2089. PubMed PMID: 20173752; PubMed Central PMCID: PMCPMC2834868.

Garcia-Lerma JG, Cong ME, Mitchell J, Youngpairoj AS, Zheng Q, Masciotra S, et al.
Intermittent prophylaxis with oral truvada protects macaques from rectal SHIV infection.
Sci Transl Med. 2010;2(14):14ra4. doi: 10.1126/scitranslmed.3000391. PubMed PMID: 20371467.

Kirmaier A, Wu F, Newman RM, Hall LR, Morgan JS, O'Connor S, et al.
TRIM5 suppresses cross-species transmission of a primate immunodeficiency virus and selects for emergence of resistant variants in the new species.
PLoS Biol. 2010;8(8). doi: 10.1371/journal.pbio.1000462. PubMed PMID: 20808775; PubMed Central PMCID: PMCPMC2927514.

Ng CT, Jaworski JP, Jayaraman P, Sutton WF, Delio P, Kuller L, et al.
Passive neutralizing antibody controls SHIV viremia and enhances B cell responses in infant macaques.
Nat Med. 2010;16(10):1117-9. Epub 2010/10/05. doi: nm.2233 [pii] 10.1038/nm.2233. PubMed PMID: 20890292; PubMed Central PMCID: PMC2952052.

Shingai M, Nishimura Y, Klein F, Mouquet H, Donau OK, Plishka R, et al.
Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia.
Nature. 2013;503(7475):277-80. doi: 10.1038/nature12746. PubMed PMID: 24172896; PubMed Central PMCID: PMCPMC4133787.

Wang X, Xu H, Pahar B, Alvarez X, Green LC, Dufour J, et al.
Simian immunodeficiency virus selectively infects proliferating CD4+ T cells in neonatal rhesus macaques.
Blood. 2010;116(20):4168-74. doi: 10.1182/blood-2010-03-273482. PubMed PMID: 20716768; PubMed Central PMCID: PMCPMC2993622.

Worobey M, Telfer P, Souquiere S, Hunter M, Coleman CA, Metzger MJ, et al.
Island biogeography reveals the deep history of SIV.
Science. 2010;329(5998):1487. doi: 10.1126/science.1193550. PubMed PMID: 20847261.


Burton DR, Hessell AJ, Keele BF, Klasse PJ, Ketas TA, Moldt B, et al.
Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody.
Proc Natl Acad Sci U S A. 2011;108(27):11181-6. doi: 10.1073/pnas.1103012108. PubMed PMID: 21690411; PubMed Central PMCID: PMCPMC3131343.

Hansen SG, Ford JC, Lewis MS, Ventura AB, Hughes CM, Coyne-Johnson L, et al.
Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine.
Nature. 2011;473(7348):523-7. Epub 2011/05/13. doi: 10.1038/nature10003. PubMed PMID: 21562493; PubMed Central PMCID: PMC3102768.

Ortiz AM, Klatt NR, Li B, Yi Y, Tabb B, Hao XP, et al.
Depletion of CD4 T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques.
J Clin Invest. 2011;121(11):4433-45. Epub 2011/10/19. doi: 10.1172/JCI46023. PubMed PMID: 22005304; PubMed Central PMCID: PMC3204830.

Paiardini M, Cervasi B, Reyes-Aviles E, Micci L, Ortiz AM, Chahroudi A, et al.
Low levels of SIV infection in sooty mangabey central memory CD(4)(+) T cells are associated with limited CCR5 expression.
Nat Med. 2011;17(7):830-6. doi: 10.1038/nm.2395. PubMed PMID: 21706028; PubMed Central PMCID: PMCPMC3253129.


Chahroudi A, Bosinger SE, Vanderford TH, Paiardini M, Silvestri G.
Natural SIV hosts: showing AIDS the door.
Science. 2012;335(6073):1188-93. doi: 10.1126/science.1217550. PubMed PMID: 22403383; PubMed Central PMCID: PMCPMC3822437.

Fukazawa Y, Park H, Cameron MJ, Lefebvre F, Lum R, Coombes N, et al.
Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines.
Nat Med. 2012;18(11):1673-81. Epub 2012/09/11. doi: 10.1038/nm.2934. PubMed PMID: 22961108; PubMed Central PMCID: PMC3493820.

Genesca M, Ma ZM, Wang Y, Assaf B, Qureshi H, Fritts L, et al.
Live-attenuated lentivirus immunization modulates innate immunity and inflammation while protecting rhesus macaques from vaginal simian immunodeficiency virus challenge.
J Virol. 2012;86(17):9188-200. doi: 10.1128/JVI.00532-12. PubMed PMID: 22696662; PubMed Central PMCID: PMCPMC3416105.

Handley SA, Thackray LB, Zhao G, Presti R, Miller AD, Droit L, et al.
Pathogenic simian immunodeficiency virus infection is associated with expansion of the enteric virome.
Cell. 2012;151(2):253-66. doi: 10.1016/j.cell.2012.09.024. PubMed PMID: 23063120; PubMed Central PMCID: PMCPMC3490196.

Mudd PA, Martins MA, Ericsen AJ, Tully DC, Power KA, Bean AT, et al.
Vaccine-induced CD8+ T cells control AIDS virus replication.
Nature. 2012;491(7422):129-33. doi: 10.1038/nature11443. PubMed PMID: 23023123; PubMed Central PMCID: PMCPMC3883109.


Barouch DH, Stephenson KE, Borducchi EN, Smith K, Stanley K, McNally AG, et al.
Protective efficacy of a global HIV-1 mosaic vaccine against heterologous SHIV challenges in rhesus monkeys.
Cell. 2013;155(3):531-9. doi: 10.1016/j.cell.2013.09.061. PubMed PMID: 24243013; PubMed Central PMCID: PMCPMC3846288.

Barouch DH, Whitney JB, Moldt B, Klein F, Oliveira TY, Liu J, et al.
Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys.
Nature. 2013;503(7475):224-8. doi: 10.1038/nature12744. PubMed PMID: 24172905; PubMed Central PMCID: PMCPMC4017780.

Hansen SG, Piatak M, Jr., Ventura AB, Hughes CM, Gilbride RM, Ford JC, et al.
Immune clearance of highly pathogenic SIV infection.
Nature. 2013;502(7469):100-4. Epub 2013/09/13. doi: 10.1038/nature12519. PubMed PMID: 24025770; PubMed Central PMCID: PMC3849456.

Hansen SG, Sacha JB, Hughes CM, Ford JC, Burwitz BJ, Scholz I, et al.
Cytomegalovirus vectors violate CD8+ T cell epitope recognition paradigms.
Science. 2013;340(6135):1237874. Epub 2013/05/25. doi: 10.1126/science.1237874. PubMed PMID: 23704576; PubMed Central PMCID: PMC3816976.

Jaworski JP, Kobie J, Brower Z, Malherbe DC, Landucci G, Sutton WF, et al.
Neutralizing polyclonal IgG present during acute infection prevents rapid disease onset in simian-human immunodeficiency virus SHIVSF162P3-infected infant rhesus macaques.
J Virol. 2013;87(19):10447-59. doi: 10.1128/JVI.00049-13. PubMed PMID: 23885083; PubMed Central PMCID: PMCPMC3807376.


Andrews CD, Spreen WR, Mohri H, Moss L, Ford S, Gettie A, Russell-Lodrigue K, Bohm RP, Cheng-Mayer C, Hong Z, Markowitz M, Ho DD.
Long-acting integrase inhibitor protects macaques from intrarectal simian/human immunodeficiency virus.
Science. 2014;343(6175):1151-4. PMCID: PMC4308974.

Chahroudi A, Cartwright E, Lee ST, Mavigner M, Carnathan DG, Lawson B, et al.
Target cell availability, rather than breast milk factors, dictates mother-to-infant transmission of SIV in sooty mangabeys and rhesus macaques.
PLoS Pathog. 2014;10(3):e1003958. doi: 10.1371/journal.ppat.1003958. PubMed PMID: 24604066; PubMed Central PMCID: PMCPMC3946396.

Mavigner M, Watkins B, Lawson B, Lee ST, Chahroudi A, Kean L, et al.
Persistence of virus reservoirs in ART-treated SHIV-infected rhesus macaques after autologous hematopoietic stem cell transplant.
PLoS Pathog. 2014;10(9):e1004406. doi: 10.1371/journal.ppat.1004406. PubMed PMID: 25254512; PubMed Central PMCID: PMC4177994.

Sandler NG, Bosinger SE, Estes JD, Zhu RT, Tharp GK, Boritz E, et al.
Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression.
Nature. 2014;511(7511):601-5. doi: 10.1038/nature13554. PubMed PMID: 25043006; PubMed Central PMCID: PMCPMC4418221.


Barouch DH, Alter G, Broge T, Linde C, Ackerman ME, Brown EP, et al.
Protective efficacy of adenovirus-protein vaccines against SIV challenges in rhesus monkeys.
Science. 2015. doi: 10.1126/science.aab3886. PubMed PMID: 26138104.

Dinh MH, Anderson MR, McRaven MD, Cianci GC, McCoombe SG, Kelley ZL, et al.
Visualization of HIV-1 interactions with penile and foreskin epithelia: clues for female-to-male HIV transmission.
PLoS Pathog. 2015;11(3):e1004729. doi: 10.1371/journal.ppat.1004729. PubMed PMID: 25748093; PubMed Central PMCID: PMCPMC4352059.

Gardner MR, Kattenhorn LM, Kondur HR, von Schaewen M, Dorfman T, Chiang JJ, et al.
AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges.
Nature. 2015;519(7541):87-91. doi: 10.1038/nature14264. PubMed PMID: 25707797; PubMed Central PMCID: PMCPMC4352131.