2020

Ahmed M, Thirunavukkarasu S, Rosa BA, Thomas KA, Das S, Rangel-Moreno J, Lu L, Mehra S, Mbandi SK, Thackray LB, Diamond MS, Murphy KM, Means T, Martin J, Kaushal D, Scriba TJ, Mitreva M, Khader SA
Immune correlates of tuberculosis disease and risk translate across species.
Sci Transl Med. 2020 Jan 29;12(528). pii: 12/528/eaay0233. doi:10.1126/scitranslmed.aay0233. 2020.

Collins JM, Siddiqa A, Jones DP, Liu K, Kempker RR, Nizam A, Shah NS, Ismail N, Ouma SG, Tukvadze N, Li S, Day CL, Rengarajan J, Brust JC, Gandhi NR, Ernst JD, Blumberg HM, Ziegler TR
Tryptophan catabolism reflects disease activity in human tuberculosis.
JCI Insight. 2020 May 21;5(10). pii: 137131. doi: 10.1172/jci.insight.137131. 2020.

Dupont M, Souriant S, Balboa L, Vu Manh TP, Pingris K, Rousset S, Cougoule C, Rombouts Y, Poincloux R, Ben Neji M, Allers C, Kaushal D, Kuroda MJ, Benet S, Martinez-Picado J, Izquierdo-Useros N, Sasiain MDC, Maridonneau-Parini I, Neyrolles O, Verollet C, Lugo-Villarino G
Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages.
Elife. 2020 Mar 30;9. pii: 52535. doi: 10.7554/eLife.52535. 2020.

Ganatra SR, Bucsan AN, Alvarez X, Kumar S, Chatterjee A, Quezada M, Fish AI, Singh DK, Singh B, Sharan R, Lee TH, Shanmugasundaram U, Velu V, Khader SA, Mehra S, Rengarajan J, Kaushal D
Anti-retroviral therapy does not reduce tuberculosis reactivation in atuberculosis-HIV co-infection model.
J Clin Invest. 2020 Jun 16. pii: 136502. doi: 10.1172/JCI136502. 2020.

Scott NR, Swanson RV, Al-Hammadi N, Domingo-Gonzalez R, Rangel-Moreno J, Kriel BA, Bucsan AN, Das S, Ahmed M, Mehra S, Treerat P, Cruz-Lagunas A, Jimenez-Alvarez L, Munoz-Torrico M, Bobadilla-Lozoya K, Vogl T, Walzl G, du Plessis N, Kaushal D, Scriba T, Zuniga J, Khader S
S100A8/A9 regulates CD11b expression and neutrophil recruitment during chronictuberculosis.
J Clin Invest. 2020 Mar 5. pii: 130546. doi: 10.1172/JCI130546. 2020.

Shanmugasundaram U, Bucsan AN, Ganatra SR, Ibegbu C, Quezada M, Blair RV, Alvarez X, Velu V, Kaushal D, Rengarajan J
Pulmonary Mycobacterium tuberculosis control associates with CXCR3- andCCR6-expressing antigen-specific Th1 and Th17 cell recruitment.
JCI Insight. 2020 Jun 16. pii: 137858. doi: 10.1172/jci.insight.137858. 2020.

Sharan R, Bucsan AN, Ganatra S, Paiardini M, Mohan M, Mehra S, Khader SA, Kaushal D
Chronic Immune Activation in TB/HIV Co-infection.
Trends Microbiol. 2020 Apr 22. pii: S0966-842X(20)30086-X. doi:10.1016/j.tim.2020.03.015. 2020.

2019

Alberto Choreno-Parra J, Bobba S, Rangel-Moreno J, Ahmed M, Mehra S, Rosa B, Martin J, Mitreva M, Kaushal D, Zuniga J, Khader SA
Mycobacterium tuberculosis HN878 infection induces human-like B cell follicles inmice.
J Infect Dis. 2019 Dec 13. pii: 5674951. doi: 10.1093/infdis/jiz663. 2019.

Ardain A, Domingo-Gonzalez R, Das S, Kazer SW, Howard NC, Singh A, Ahmed M, Nhamoyebonde S, Rangel-Moreno J, Ogongo P, Lu L, Ramsuran D, de la Luz Garcia-Hernandez M, K Ulland T, Darby M, Park E, Karim F, Melocchi L, Madansein R, Dullabh KJ, Dunlap M, Marin-Agudelo N, Ebihara T, Ndung'u T, Kaushal D, Pym AS, Kolls JK, Steyn A, Zuniga J, Horsnell W, Yokoyama WM, Shalek AK, Kloverpris HN, Colonna M, Leslie A, Khader SA
Group 3 innate lymphoid cells mediate early protective immunity againsttuberculosis.
Nature. 2019 Jun;570(7762):528-532. doi: 10.1038/s41586-019-1276-2. Epub 2019 Jun5. 2019.

Ardain A, Domingo-Gonzalez R, Das S, Kazer SW, Howard NC, Singh A, Ahmed M, Nhamoyebonde S, Rangel-Moreno J, Ogongo P, Lu L, Ramsuran D, de la Luz Garcia-Hernandez M, Ulland TK, Darby M, Park E, Karim F, Melocchi L, Madansein R, Dullabh KJ, Dunlap M, Marin-Agudelo N, Ebihara T, Ndung'u T, Kaushal D, Pym AS, Kolls JK, Steyn A, Zuniga J, Horsnell W, Yokoyama WM, Shalek AK, Kloverpris HN, Colonna M, Leslie A, Khader SA
Publisher Correction: Group 3 innate lymphoid cells mediate early protectiveimmunity against tuberculosis.
Nature. 2019 Aug;572(7768):E10. doi: 10.1038/s41586-019-1458-y. 2019.

Bucsan AN, Chatterjee A, Singh DK, Foreman TW, Lee TH, Threeton B, Kirkpatrick MG, Ahmed M, Golden N, Alvarez X, Hoxie JA, Mehra S, Rengarajan J, Khader SA, Kaushal D
Mechanisms of reactivation of latent tuberculosis infection due to SIVcoinfection.
J Clin Invest. 2019 Oct 28. pii: 125810. doi: 10.1172/JCI125810. 2019.

Bucsan AN, Mehra S, Khader SA, Kaushal D
The current state of animal models and genomic approaches towards identifying andvalidating molecular determinants of Mycobacterium tuberculosis infection and tuberculosis disease.
Pathog Dis. 2019 Jun 1;77(4). pii: 5543892. doi: 10.1093/femspd/ftz037. 2019.

Bucsan AN, Rout N, Foreman TW, Khader SA, Rengarajan J, Kaushal D
Mucosal-activated invariant T cells do not exhibit significant lung recruitmentand proliferation profiles in macaques in response to infection with Mycobacterium tuberculosis CDC1551.
Tuberculosis (Edinb). 2019 May;116S:S11-S18. doi: 10.1016/j.tube.2019.04.006.Epub 2019 Apr 26. 2019.

Corleis B, Bucsan AN, Deruaz M, Vrbanac VD, Lisanti-Park AC, Gates SJ, Linder AH, Paer JM, Olson GS, Bowman BA, Schiff AE, Medoff BD, Tager AM, Luster AD, Khader SA, Kaushal D, Kwon DS
HIV-1 and SIV Infection Are Associated with Early Loss of Lung Interstitial CD4+ T Cells and Dissemination of Pulmonary Tuberculosis.
Cell Rep. 2019 Feb 5;26(6):1409-1418.e5. doi: 10.1016/j.celrep.2019.01.021. 2019.

Foreman TW, Bucsan AN, Mehra S, Peloquin C, Doyle LA, Russell-Lodrigue K, Gandhi NR, Altman J, Day CL, Ernst JD, Blumberg HM, Rengarajan J, Kaushal D
Isoniazid and Rifapentine Treatment Eradicates Persistent Mycobacteriumtuberculosis in Macaques.
Am J Respir Crit Care Med. 2019 Oct 24. doi: 10.1164/rccm.201903-0646OC. 2019.

Gautam US, Mehra S, Kumari P, Alvarez X, Niu T, Tyagi JS, Kaushal D
Mycobacterium tuberculosis sensor kinase DosS modulates the autophagosome in aDosR-independent manner.
Commun Biol. 2019 Sep 20;2(1):349. doi: 10.1038/s42003-019-0594-0. 2019.

Marin ND, Dunlap MD, Kaushal D, Khader SA
Friend or Foe: The Protective and Pathological Roles of InducibleBronchus-Associated Lymphoid Tissue in Pulmonary Diseases.
J Immunol. 2019 May 1;202(9):2519-2526. doi: 10.4049/jimmunol.1801135. 2019.

Souriant S, Balboa L, Dupont M, Pingris K, Kviatcovsky D, Cougoule C, Lastrucci C, Bah A, Gasser R, Poincloux R, Raynaud-Messina B, Al Saati T, Inwentarz S, Poggi S, Morana EJ, Gonzalez-Montaner P, Corti M, Lagane B, Vergne I, Allers C, Kaushal D, Kuroda MJ, Sasiain MDC, Neyrolles O, Maridonneau-Parini I, Lugo-Villarino G, Verollet C
Tuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages.
Cell Rep. 2019 Mar 26;26(13):3586-3599.e7. doi: 10.1016/j.celrep.2019.02.091. 2019.

Wu Q, Hossfeld A, Gerberick A, Saljoughian N, Tiwari C, Mehra S, Ganesan LP, Wozniak DJ, Rajaram MVS
Mycobacterium tuberculosis enhances macrophage P-glycoprotein (MDR1) expressionand activity to promote intracellular survival during anti-TB drug treatment.
J Infect Dis. 2019 Aug 14. pii: 5549997. doi: 10.1093/infdis/jiz405. 2019.

Yee JL, Prongay K, Miles B, Smedley J, Hansen SG, Axthelm MK, Ardeshir A, Van Rompay KKA, Timmel G, Roberts JA
Interferon-Gamma test for the detection of Mycobacterium tuberculosis complexinfection in Macaca mulatta and other non-human primates.
J Med Primatol. 2019 Aug;48(4):260-263. doi: 10.1111/jmp.12420. Epub 2019 May 6. 2019.

2018

Dunlap MD, Howard N, Das S, Scott N, Ahmed M, Prince O, Rangel-Moreno J, Rosa BA, Martin J, Kaushal D, Kaplan G, Mitreva M, Kim KW, Randolph GJ, Khader SA
A novel role for C-C motif chemokine receptor 2 during infection withhypervirulent Mycobacterium tuberculosis.
Mucosal Immunol. 2018 Nov;11(6):1727-1742. doi: 10.1038/s41385-018-0071-y. Epub2018 Aug 16. 2018.

Gautam US, Foreman TW, Bucsan AN, Veatch AV, Alvarez X, Adekambi T, Golden NA, Gentry KM, Doyle-Meyers LA, Russell-Lodrigue KE, Didier PJ, Blanchard JL, Kousoulas KG, Lackner AA, Kalman D, Rengarajan J, Khader SA, Kaushal D, Mehra S
In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma andaugments immune-mediated control of Mycobacterium tuberculosis.
Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):E62-E71. doi:10.1073/pnas.1711373114. Epub 2017 Dec 18. 2018.

Hansen SG, Zak DE, Xu G, Ford JC, Marshall EE, Malouli D, Gilbride RM, Hughes CM, Ventura AB, Ainslie E, Randall KT, Selseth AN, Rundstrom P, Herlache L, Lewis MS, Park H, Planer SL, Turner JM, Fischer M, Armstrong C, Zweig RC, Valvo J, Braun JM, Shankar S, Lu L, Sylwester AW, Legasse AW, Messerle M, Jarvis MA, Amon LM, Aderem A, Alter G, Laddy DJ, Stone M, Bonavia A, Evans TG, Axthelm MK, Fruh K, Edlefsen PT, Picker LJ
Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine.
Nat Med. 2018 Feb;24(2):130-143. doi: 10.1038/nm.4473. Epub 2018 Jan 15. 2018.

Kuroda MJ, Sugimoto C, Cai Y, Merino KM, Mehra S, Arainga M, Roy CJ, Midkiff CC, Alvarez X, Didier ES, Kaushal D
High Turnover of Tissue Macrophages Contributes to Tuberculosis Reactivation inSimian Immunodeficiency Virus-Infected Rhesus Macaques.
J Infect Dis. 2018 May 25;217(12):1865-1874. doi: 10.1093/infdis/jix625. 2018.

Laddy DJ, Bonavia A, Hanekom WA, Kaushal D, Williams A, Roederer M, Seder RA, Sharpe S, Verreck FAW, Darrah PA
Toward Tuberculosis Vaccine Development: Recommendations for Nonhuman PrimateStudy Design.
Infect Immun. 2018 Jan 22;86(2). pii: IAI.00776-17. doi: 10.1128/IAI.00776-17.Print 2018 Feb. 2018.

Rodgers MA, Ameel C, Ellis-Connell AL, Balgeman AJ, Maiello P, Barry GL, Friedrich TC, Klein E, O'Connor SL, Scanga CA
Preexisting Simian Immunodeficiency Virus Infection Increases Susceptibility toTuberculosis in Mauritian Cynomolgus Macaques.
Infect Immun. 2018 Nov 20;86(12). pii: IAI.00565-18. doi: 10.1128/IAI.00565-18.Print 2018 Dec. 2018.

Veatch AV, Kaushal D
Opening Pandora's Box: Mechanisms of Mycobacterium tuberculosis Resuscitation.
Trends Microbiol. 2018 Feb;26(2):145-157. doi: 10.1016/j.tim.2017.08.001. Epub2017 Sep 11. 2018.

Walters LC, Harlos K, Brackenridge S, Rozbesky D, Barrett JR, Jain V, Walter TS, O'Callaghan CA, Borrow P, Toebes M, Hansen SG, Sacha JB, Abdulhaqq S, Greene JM, Fruh K, Marshall E, Picker LJ, Jones EY, McMichael AJ, Gillespie GM
Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pockettolerability and conformationally malleable peptide binding.
Nat Commun. 2018 Aug 7;9(1):3137. doi: 10.1038/s41467-018-05459-z. 2018.

Whatney WE, Gandhi NR, Lindestam Arlehamn CS, Nizam A, Wu H, Quezada MJ, Campbell A, Allana S, Kabongo MM, Khayumbi J, Muchiri B, Ongalo J, Tonui J, Sasser LE, Fergus TJ, Ouma GS, Ouma SG, Beck AA, Mulligan MJ, Oladele A, Kaushal D, Cain KP, Waller L, Blumberg HM, Altman JD, Ernst JD, Rengarajan J, Day CL
A High Throughput Whole Blood Assay for Analysis of Multiple Antigen-Specific TCell Responses in Human Mycobacterium tuberculosis Infection.
J Immunol. 2018 Apr 15;200(8):3008-3019. doi: 10.4049/jimmunol.1701737. Epub 2018Mar 14. 2018.

2017

Cheng CY, Gutierrez NM, Marzuki MB, Lu X, Foreman TW, Paleja B, Lee B, Balachander A, Chen J, Tsenova L, Kurepina N, Teng KWW, West K, Mehra S, Zolezzi F, Poidinger M, Kreiswirth B, Kaushal D, Kornfeld H, Newell EW, Singhal A
Host sirtuin 1 regulates mycobacterial immunopathogenesis and represents atherapeutic target against tuberculosis.
Sci Immunol. 2017 Mar;2(9). doi: 10.1126/sciimmunol.aaj1789. Epub 2017 Mar 24. 2017.

Day CL, Abrahams DA, Harris LD, van Rooyen M, Stone L, de Kock M, Hanekom WA
HIV-1 Infection Is Associated with Depletion and Functional Impairment ofMycobacterium tuberculosis-Specific CD4 T Cells in Individuals with Latent Tuberculosis Infection.
J Immunol. 2017 Sep 15;199(6):2069-2080. doi: 10.4049/jimmunol.1700558. Epub 2017Jul 31. 2017.

Ellis A, Balgeman A, Rodgers M, Updike C, Tomko J, Maiello P, Scanga CA, O'Connor SL
Characterization of T Cells Specific for CFP-10 and ESAT-6 in Mycobacteriumtuberculosis-Infected Mauritian Cynomolgus Macaques.
Infect Immun. 2017 Mar 23;85(4). pii: IAI.01009-16. doi: 10.1128/IAI.01009-16.Print 2017 Apr. 2017.

Foreman TW, Mehra S, Lackner AA, Kaushal D
Translational Research in the Nonhuman Primate Model of Tuberculosis.
ILAR J. 2017 Dec 1;58(2):151-159. doi: 10.1093/ilar/ilx015. 2017.

Foreman TW, Veatch AV, LoBato DN, Didier PJ, Doyle-Meyers LA, Russell-Lodrigue KE, Lackner AA, Kousoulas KG, Khader SA, Kaushal D, Mehra S
Nonpathologic Infection of Macaques by an Attenuated Mycobacterial Vaccine Is NotReactivated in the Setting of HIV Co-Infection.
Am J Pathol. 2017 Dec;187(12):2811-2820. doi: 10.1016/j.ajpath.2017.08.014. Epub 2017 Sep 19. 2017.

Greene JM, Dash P, Roy S, McMurtrey C, Awad W, Reed JS, Hammond KB, Abdulhaqq S, Wu HL, Burwitz BJ, Roth BF, Morrow DW, Ford JC, Xu G, Bae JY, Crank H, Legasse AW, Dang TH, Greenaway HY, Kurniawan M, Gold MC, Harriff MJ, Lewinsohn DA, Park BS, Axthelm MK, Stanton JJ, Hansen SG, Picker LJ, Venturi V, Hildebrand W, Thomas PG, Lewinsohn DM, Adams EJ, Sacha JB
MR1-restricted mucosal-associated invariant T (MAIT) cells respond tomycobacterial vaccination and infection in nonhuman primates.
Mucosal Immunol. 2017 May;10(3):802-813. doi: 10.1038/mi.2016.91. Epub 2016 Oct19. 2017.

Hudock TA, Foreman TW, Bandyopadhyay N, Gautam US, Veatch AV, LoBato DN, Gentry KM, Golden NA, Cavigli A, Mueller M, Hwang SA, Hunter RL, Alvarez X, Lackner AA, Bader JS, Mehra S, Kaushal D
Hypoxia Sensing and Persistence Genes Are Expressed during the IntragranulomatousSurvival of Mycobacterium tuberculosis.
Am J Respir Cell Mol Biol. 2017 May;56(5):637-647. doi: 10.1165/rcmb.2016-0239OC. 2017.

Jensen K, Dela Pena-Ponce MG, Piatak M Jr, Shoemaker R, Oswald K, Jacobs WR Jr, Fennelly G, Lucero C, Mollan KR, Hudgens MG, Amedee A, Kozlowski PA, Estes JD, Lifson JD, Van Rompay KK, Larsen M, De Paris K
Balancing Trained Immunity with Persistent Immune Activation and the Risk ofSimian Immunodeficiency Virus Infection in Infant Macaques Vaccinated with Attenuated Mycobacterium tuberculosis or Mycobacterium bovis BCG Vaccine.
Clin Vaccine Immunol. 2017 Jan 5;24(1). pii: CVI.00360-16. doi:10.1128/CVI.00360-16. Print 2017 Jan. 2017.

Kim J, Coble DJ, Salyards GW, Bower JK, Rinaldi WJ, Plauche GB, Habing GG
Antimicrobial Use for and Resistance of Zoonotic Bacteria Recovered from NonhumanPrimates.
Comp Med. 2017 Feb 1;67(1):79-86. 2017.

Naffin-Olivos JL, Daab A, White A, Goldfarb NE, Milne AC, Liu D, Baikovitz J, Dunn BM, Rengarajan J, Petsko GA, Ringe D
Structure Determination of Mycobacterium tuberculosis Serine Protease Hip1(Rv2224c).
Biochemistry. 2017 May 2;56(17):2304-2314. doi: 10.1021/acs.biochem.6b01066. Epub2017 Apr 7. 2017.

Phillips BL, Gautam US, Bucsan AN, Foreman TW, Golden NA, Niu T, Kaushal D, Mehra S
LAG-3 potentiates the survival of Mycobacterium tuberculosis in host phagocytesby modulating mitochondrial signaling in an in-vitro granuloma model.
PLoS One. 2017 Sep 7;12(9):e0180413. doi: 10.1371/journal.pone.0180413.eCollection 2017. 2017.

Shipley ST, Johnson DK, Roodgar M, Smith DG, Montgomery CA, Lloyd SM, Higgins JA, Kriel EH, Klein HJ, Porter WP, Nazareno JB, Houghton PW, Panda A, DeTolla LJ
Mycobacterium kansasii Isolated from Tuberculinpositive Rhesus Macaques (Macacamulatta) in the Absence of Disease.
Comp Med. 2017 Aug 1;67(4):368-375. 2017.

Turner RD, Chiu C, Churchyard GJ, Esmail H, Lewinsohn DM, Gandhi NR, Fennelly KP
Tuberculosis Infectiousness and Host Susceptibility.
J Infect Dis. 2017 Nov 3;216(suppl_6):S636-S643. doi: 10.1093/infdis/jix361. 2017.

2016

Foreman TW, Mehra S, LoBato DN, Malek A, Alvarez X, Golden NA, Bucsan AN, Didier PJ, Doyle-Meyers LA, Russell-Lodrigue KE, Roy CJ, Blanchard J, Kuroda MJ, Lackner AA, Chan J, Khader SA, Jacobs WR Jr, Kaushal D
CD4+ T-cell-independent mechanisms suppress reactivation of latent tuberculosisin a macaque model of HIV coinfection.
Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5636-44. doi:10.1073/pnas.1611987113. Epub 2016 Sep 6. 2016.

Gasper MA, Biswas SP, Fisher BS, Ehnert SC, Sherman DR, Sodora DL
Nonpathogenic SIV and Pathogenic HIV Infections Associate with Disparate InnateCytokine Signatures in Response to Mycobacterium bovis BCG.
PLoS One. 2016 Aug 9;11(8):e0158149. doi: 10.1371/journal.pone.0158149.eCollection 2016. 2016.

Jensen K, Nabi R, Van Rompay KKA, Robichaux S, Lifson JD, Piatak M Jr, Jacobs WR Jr, Fennelly G, Canfield D, Mollan KR, Hudgens MG, Larsen MH, Amedee AM, Kozlowski PA, De Paris K
Vaccine-Elicited Mucosal and Systemic Antibody Responses Are Associated withReduced Simian Immunodeficiency Viremia in Infant Rhesus Macaques.
J Virol. 2016 Jul 27;90(16):7285-7302. doi: 10.1128/JVI.00481-16. Print 2016 Aug 15. 2016.

Nandakumar S, Kannanganat S, Dobos KM, Lucas M, Spencer JS, Amara RR, Plikaytis BB, Posey JE, Sable SB
Boosting BCG-primed responses with a subunit Apa vaccine during the waning phase improves immunity and imparts protection against Mycobacterium tuberculosis.
Sci Rep. 2016 May 13;6:25837. doi: 10.1038/srep25837. 2016.

Saeidi A, Ellegard R, Yong YK, Tan HY, Velu V, Ussher JE, Larsson M, Shankar EM
Functional role of mucosal-associated invariant T cells in HIV infection.
J Leukoc Biol. 2016 Aug;100(2):305-14. doi: 10.1189/jlb.4RU0216-084R. Epub 2016Jun 2. 2016.

Veatch AV, Niu T, Caskey J, McGillivray A, Gautam US, Subramanian R, Kousoulas KG, Mehra S, Kaushal D
Sequencing-relative to hybridization-based transcriptomics approaches betterdefine Mycobacterium tuberculosis stress-response regulons.
Tuberculosis (Edinb). 2016 Dec;101S:S9-S17. doi: 10.1016/j.tube.2016.09.020. Epub2016 Sep 28. 2016.

Winthrop K, Rivera A, Engelmann F, Rose S, Lewis A, Ku J, Bermudez L, Messaoudi I
A Rhesus Macaque Model of Pulmonary Nontuberculous Mycobacterial Disease.
Am J Respir Cell Mol Biol. 2016 Feb;54(2):170-6. doi: 10.1165/rcmb.2015-0256RC. 2016.

2015

Adekambi T, Ibegbu CC, Cagle S, Kalokhe AS, Wang YF, Hu Y, Day CL, Ray SM, Rengarajan J
Biomarkers on patient T cells diagnose active tuberculosis and monitor treatment response.
J Clin Invest. 2015 Sep;125(9):3723. doi: 10.1172/JCI83279. Epub 2015 Sep 1. 2015.

Blakney AK, Tchakoute CT, Hesseling AC, Kidzeru EB, Jones CE, Passmore JA, Sodora DL, Gray CM, Jaspan HB
Delayed BCG vaccination results in minimal alterations in T cell immunogenicityof acellular pertussis and tetanus immunizations in HIV-exposed infants.
Vaccine. 2015 Sep 11;33(38):4782-9. doi: 10.1016/j.vaccine.2015.07.096. Epub 2015Aug 7. 2015.

Gautam US, McGillivray A, Mehra S, Didier PJ, Midkiff CC, Kissee RS, Golden NA, Alvarez X, Niu T, Rengarajan J, Sherman DR, Kaushal D
DosS Is required for the complete virulence of mycobacterium tuberculosis in micewith classical granulomatous lesions.
Am J Respir Cell Mol Biol. 2015 Jun;52(6):708-16. doi: 10.1165/rcmb.2014-0230OC. 2015.

Gautam US, Mehra S, Kaushal D
In-Vivo Gene Signatures of Mycobacterium tuberculosis in C3HeB/FeJ Mice.
PLoS One. 2015 Aug 13;10(8):e0135208. doi: 10.1371/journal.pone.0135208.eCollection 2015. 2015.

Kalokhe AS, Adekambi T, Ibegbu CC, Ray SM, Day CL, Rengarajan J
Impaired degranulation and proliferative capacity of Mycobacteriumtuberculosis-specific CD8+ T cells in HIV-infected individuals with latent tuberculosis.
J Infect Dis. 2015 Feb 15;211(4):635-40. doi: 10.1093/infdis/jiu505. Epub 2014Sep 9. 2015.

Kaushal D, Foreman TW, Gautam US, Alvarez X, Adekambi T, Rangel-Moreno J, Golden NA, Johnson AM, Phillips BL, Ahsan MH, Russell-Lodrigue KE, Doyle LA, Roy CJ, Didier PJ, Blanchard JL, Rengarajan J, Lackner AA, Khader SA, Mehra S
Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strongcentral memory responses and protects against tuberculosis.
Nat Commun. 2015 Oct 13;6:8533. doi: 10.1038/ncomms9533. 2015.

Levine DM, Dutta NK, Eckels J, Scanga C, Stein C, Mehra S, Kaushal D, Karakousis PC, Salamon H
A tuberculosis ontology for host systems biology.
Tuberculosis (Edinb). 2015 Sep;95(5):570-4. doi: 10.1016/j.tube.2015.05.012. Epub2015 Jun 30. 2015.

McGillivray A, Golden NA, Kaushal D
The Mycobacterium tuberculosis Clp gene regulator is required for in vitroreactivation from hypoxia-induced dormancy.
J Biol Chem. 2015 Jan 23;290(4):2351-67. doi: 10.1074/jbc.M114.615534. Epub 2014 Nov 24. 2015.

Mehra S, Foreman TW, Didier PJ, Ahsan MH, Hudock TA, Kissee R, Golden NA, Gautam US, Johnson AM, Alvarez X, Russell-Lodrigue KE, Doyle LA, Roy CJ, Niu T, Blanchard JL, Khader SA, Lackner AA, Sherman DR, Kaushal D
The DosR Regulon Modulates Adaptive Immunity and Is Essential for Mycobacteriumtuberculosis Persistence.
Am J Respir Crit Care Med. 2015 May 15;191(10):1185-96. doi:10.1164/rccm.201408-1502OC. 2015.

Mothe BR, Lindestam Arlehamn CS, Dow C, Dillon MBC, Wiseman RW, Bohn P, Karl J, Golden NA, Gilpin T, Foreman TW, Rodgers MA, Mehra S, Scriba TJ, Flynn JL, Kaushal D, O'Connor DH, Sette A
The TB-specific CD4(+) T cell immune repertoire in both cynomolgus and rhesusmacaques largely overlap with humans.
Tuberculosis (Edinb). 2015 Dec;95(6):722-735. doi: 10.1016/j.tube.2015.07.005.Epub 2015 Aug 28. 2015.

Nakaya HI, Pulendran B
Vaccinology in the era of high-throughput biology.
Philos Trans R Soc Lond B Biol Sci. 2015 Jun 19;370(1671). pii: rstb.2014.0146.doi: 10.1098/rstb.2014.0146. 2015.

Phillips BL, Mehra S, Ahsan MH, Selman M, Khader SA, Kaushal D
LAG3 expression in active Mycobacterium tuberculosis infections.
Am J Pathol. 2015 Mar;185(3):820-33. doi: 10.1016/j.ajpath.2014.11.003. Epub 2014Dec 27. 2015.

Roodgar M, Ross CT, Tarara R, Lowenstine L, Dandekar S, Smith DG
Gene expression and TB pathogenesis in rhesus macaques: TR4, CD40, CD40L, FAS(CD95), and TNF are host genetic markers in peripheral blood mononuclear cells that are associated with severity of TB lesions.
Infect Genet Evol. 2015 Dec;36:396-409. doi: 10.1016/j.meegid.2015.10.010. Epub2015 Oct 19. 2015.

Rosenbaum M, Mendoza P, Ghersi BM, Wilbur AK, Perez-Brumer A, Cavero Yong N, Kasper MR, Montano S, Zunt JR, Jones-Engel L
Detection of Mycobacterium tuberculosis Complex in New World Monkeys in Peru.
Ecohealth. 2015 Jun;12(2):288-97. doi: 10.1007/s10393-014-0996-x. Epub 2014 Dec17. 2015.

Rozot V, Patrizia A, Vigano S, Mazza-Stalder J, Idrizi E, Day CL, Perreau M, Lazor-Blanchet C, Ohmiti K, Goletti D, Bart PA, Hanekom W, Scriba TJ, Nicod L, Pantaleo G, Harari A
Combined use of Mycobacterium tuberculosis-specific CD4 and CD8 T-cell responses is a powerful diagnostic tool of active tuberculosis.
Clin Infect Dis. 2015 Feb 1;60(3):432-7. doi: 10.1093/cid/ciu795. Epub 2014 Oct31. 2015.

Tchakoute CT, Hesseling AC, Kidzeru EB, Gamieldien H, Passmore JA, Jones CE, Gray CM, Sodora DL, Jaspan HB
Delaying BCG vaccination until 8 weeks of age results in robust BCG-specificT-cell responses in HIV-exposed infants.
J Infect Dis. 2015 Feb 1;211(3):338-46. doi: 10.1093/infdis/jiu434. Epub 2014 Aug8. 2015.

Venketaraman V, Kaushal D, Saviola B
Mycobacterium tuberculosis.
J Immunol Res. 2015;2015:857598. doi: 10.1155/2015/857598. Epub 2015 Aug 4. 2015.

2014

Darrah PA, Bolton DL, Lackner AA, Kaushal D, Aye PP, Mehra S, Blanchard JL, Didier PJ, Roy CJ, Rao SS, Hokey DA, Scanga CA, Sizemore DR, Sadoff JC, Roederer M, Seder RA
Aerosol vaccination with AERAS-402 elicits robust cellular immune responses inthe lungs of rhesus macaques but fails to protect against high-dose Mycobacterium tuberculosis challenge.
J Immunol. 2014 Aug 15;193(4):1799-811. doi: 10.4049/jimmunol.1400676. Epub 2014 Jul 14. 2014.

Dutta NK, McLachlan J, Mehra S, Kaushal D
Humoral and lung immune responses to Mycobacterium tuberculosis infection in aprimate model of protection().
Trials Vaccinol. 2014 Mar 13;3:47-51. doi: 10.1016/j.trivac.2014.02.001. 2014.

Gautam US, Mehra S, Ahsan MH, Alvarez X, Niu T, Kaushal D
Role of TNF in the altered interaction of dormant Mycobacterium tuberculosis withhost macrophages.
PLoS One. 2014 Apr 17;9(4):e95220. doi: 10.1371/journal.pone.0095220. eCollection2014. 2014.

Gopal R, Monin L, Slight S, Uche U, Blanchard E, Fallert Junecko BA, Ramos-Payan R, Stallings CL, Reinhart TA, Kolls JK, Kaushal D, Nagarajan U, Rangel-Moreno J, Khader SA
Unexpected role for IL-17 in protective immunity against hypervirulentMycobacterium tuberculosis HN878 infection.
PLoS Pathog. 2014 May 15;10(5):e1004099. doi: 10.1371/journal.ppat.1004099.eCollection 2014 May. 2014.

Hudock TA, Kaushal D
A novel microdissection approach to recovering mycobacterium tuberculosisspecific transcripts from formalin fixed paraffin embedded lung granulomas.
J Vis Exp. 2014 Jun 5;(88). doi: 10.3791/51693. 2014.

Hudock TA, Lackner AA, Kaushal D
Microdissection approaches in tuberculosis research.
J Med Primatol. 2014 Oct;43(5):294-7. doi: 10.1111/jmp.12141. Epub 2014 Aug 28. 2014.

Luo Q, Mehra S, Golden NA, Kaushal D, Lacey MR
Identification of biomarkers for tuberculosis susceptibility via integratedanalysis of gene expression and longitudinal clinical data.
Front Genet. 2014 Jul 24;5:240. doi: 10.3389/fgene.2014.00240. eCollection 2014. 2014.

Madan-Lala R, Sia JK, King R, Adekambi T, Monin L, Khader SA, Pulendran B, Rengarajan J
Mycobacterium tuberculosis impairs dendritic cell functions through the serinehydrolase Hip1.
J Immunol. 2014 May 1;192(9):4263-72. doi: 10.4049/jimmunol.1303185. Epub 2014Mar 21. 2014.

McGillivray A, Golden NA, Gautam US, Mehra S, Kaushal D
The Mycobacterium tuberculosis Rv2745c plays an important role in responding toredox stress.
PLoS One. 2014 Apr 4;9(4):e93604. doi: 10.1371/journal.pone.0093604. eCollection 2014. 2014.

Naffin-Olivos JL, Georgieva M, Goldfarb N, Madan-Lala R, Dong L, Bizzell E, Valinetz E, Brandt GS, Yu S, Shabashvili DE, Ringe D, Dunn BM, Petsko GA, Rengarajan J
Mycobacterium tuberculosis Hip1 modulates macrophage responses throughproteolysis of GroEL2.
PLoS Pathog. 2014 May 15;10(5):e1004132. doi: 10.1371/journal.ppat.1004132.eCollection 2014 May. 2014.

Nandakumar S, Kannanganat S, Posey JE, Amara RR, Sable SB
Attrition of T-cell functions and simultaneous upregulation of inhibitory markerscorrespond with the waning of BCG-induced protection against tuberculosis in mice.
PLoS One. 2014 Nov 24;9(11):e113951. doi: 10.1371/journal.pone.0113951.eCollection 2014. 2014.

Ravindran R, Krishnan VV, Dhawan R, Wunderlich ML, Lerche NW, Flynn JL, Luciw PA, Khan IH
Plasma antibody profiles in non-human primate tuberculosis.
J Med Primatol. 2014 Apr;43(2):59-71. doi: 10.1111/jmp.12097. Epub 2014 Jan 22. 2014.

Rivera-Hernandez T, Carnathan DG, Moyle PM, Toth I, West NP, Young PR, Silvestri G, Walker MJ
The contribution of non-human primate models to the development of humanvaccines.
Discov Med. 2014 Dec;18(101):313-22. 2014.

2013

Cepeda M, Salas M, Folwarczny J, Leandro AC, Hodara VL, de la Garza MA, Dick EJ Jr, Owston M, Armitige LY, Gauduin MC
Establishment of a neonatal rhesus macaque model to study Mycobacteriumtuberculosis infection.
Tuberculosis (Edinb). 2013 Dec;93 Suppl:S51-9. doi:10.1016/S1472-9792(13)70011-8. 2013.

Gopal R, Monin L, Torres D, Slight S, Mehra S, McKenna KC, Fallert Junecko BA, Reinhart TA, Kolls J, Baez-Saldana R, Cruz-Lagunas A, Rodriguez-Reyna TS, Kumar NP, Tessier P, Roth J, Selman M, Becerril-Villanueva E, Baquera-Heredia J, Cumming B, Kasprowicz VO, Steyn AJ, Babu S, Kaushal D, Zuniga J, Vogl T, Rangel-Moreno J, Khader SA
S100A8/A9 proteins mediate neutrophilic inflammation and lung pathology duringtuberculosis.
Am J Respir Crit Care Med. 2013 Nov 1;188(9):1137-46. doi:10.1164/rccm.201304-0803OC. 2013.

Jensen K, Pena MG, Wilson RL, Ranganathan UD, Jacobs WR Jr, Fennelly G, Larsen M, Van Rompay KK, Kozlowski PA, Abel K
A neonatal oral Mycobacterium tuberculosis-SIV prime / intramuscular MVA-SIVboost combination vaccine induces both SIV and Mtb-specific immune responses in infant macaques.
Trials Vaccinol. 2013 Nov 1;2:53-63. doi: 10.1016/j.trivac.2013.09.005. 2013.

Kasmar AG, Van Rhijn I, Magalhaes KG, Young DC, Cheng TY, Turner MT, Schiefner A, Kalathur RC, Wilson IA, Bhati M, Gras S, Birkinshaw RW, Tan LL, Rossjohn J, Shires J, Jakobsen S, Altman JD, Moody DB
Cutting Edge: CD1a tetramers and dextramers identify human lipopeptide-specific Tcells ex vivo.
J Immunol. 2013 Nov 1;191(9):4499-503. doi: 10.4049/jimmunol.1301660. Epub 2013Oct 2. 2013.

Leandro AC, Rocha MA, Lamoglia-Souza A, VandeBerg JL, Rolla VC, Bonecini-Almeida Mda G
No association of IFNG+874T/A SNP and NOS2A-954G/C SNP variants with nitric oxideradical serum levels or susceptibility to tuberculosis in a Brazilian population subset.
Biomed Res Int. 2013;2013:901740. doi: 10.1155/2013/901740. Epub 2013 Aug 18. 2013.

Ly D, Kasmar AG, Cheng TY, de Jong A, Huang S, Roy S, Bhatt A, van Summeren RP, Altman JD, Jacobs WR Jr, Adams EJ, Minnaard AJ, Porcelli SA, Moody DB
CD1c tetramers detect ex vivo T cell responses to processed phosphomycoketideantigens.
J Exp Med. 2013 Apr 8;210(4):729-41. doi: 10.1084/jem.20120624. Epub 2013 Mar 25. 2013.

Martinez AN, Mehra S, Kaushal D
Role of interleukin 6 in innate immunity to Mycobacterium tuberculosis infection.
J Infect Dis. 2013 Apr 15;207(8):1253-61. doi: 10.1093/infdis/jit037. Epub 2013Jan 28. 2013.

Mehra S, Alvarez X, Didier PJ, Doyle LA, Blanchard JL, Lackner AA, Kaushal D
Granuloma correlates of protection against tuberculosis and mechanisms of immune modulation by Mycobacterium tuberculosis.
J Infect Dis. 2013 Apr;207(7):1115-27. doi: 10.1093/infdis/jis778. Epub 2012 Dec 18. 2013.

Nandakumar S, Kannanganat S, Dobos KM, Lucas M, Spencer JS, Fang S, McDonald MA, Pohl J, Birkness K, Chamcha V, Ramirez MV, Plikaytis BB, Posey JE, Amara RR, Sable SB
O-mannosylation of the Mycobacterium tuberculosis adhesin Apa is crucial for Tcell antigenicity during infection but is expendable for protection.
PLoS Pathog. 2013;9(10):e1003705. doi: 10.1371/journal.ppat.1003705. Epub 2013Oct 10. 2013.

Pacheco SA, Powers KM, Engelmann F, Messaoudi I, Purdy GE
Autophagic Killing Effects against Mycobacterium tuberculosis by AlveolarMacrophages from Young and Aged Rhesus Macaques.
PLoS One. 2013 Jun 18;8(6):e66985. doi: 10.1371/journal.pone.0066985. Print 2013. 2013.

Ravindran R, Krishnan VV, Khanum A, Luciw PA, Khan IH
Exploratory study on plasma immunomodulator and antibody profiles in tuberculosispatients.
Clin Vaccine Immunol. 2013 Aug;20(8):1283-90. doi: 10.1128/CVI.00213-13. Epub2013 Jun 12. 2013.

Roodgar M, Lackner A, Kaushal D, Sankaran S, Dandekar S, Trask JS, Drake C, Smith DG
Expression levels of 10 candidate genes in lung tissue of vaccinated andTB-infected cynomolgus macaques.
J Med Primatol. 2013 Jun;42(3):161-4. 2013.

Slight SR, Rangel-Moreno J, Gopal R, Lin Y, Fallert Junecko BA, Mehra S, Selman M, Becerril-Villanueva E, Baquera-Heredia J, Pavon L, Kaushal D, Reinhart TA, Randall TD, Khader SA
CXCR5(+) T helper cells mediate protective immunity against tuberculosis.
J Clin Invest. 2013 Feb;123(2):712-26. doi: 10.1172/JCI65728. Epub 2013 Jan 2. 2013.

Van Rhijn I, Kasmar A, de Jong A, Gras S, Bhati M, Doorenspleet ME, de Vries N, Godfrey DI, Altman JD, de Jager W, Rossjohn J, Moody DB
A conserved human T cell population targets mycobacterial antigens presented byCD1b.
Nat Immunol. 2013 Jul;14(7):706-13. doi: 10.1038/ni.2630. Epub 2013 Jun 2. 2013.

2012

Chromy BA, Fodor IK, Montgomery NK, Luciw PA, McCutchen-Maloney SL
Cluster analysis of host cytokine responses to biodefense pathogens in a wholeblood ex vivo exposure model (WEEM).
BMC Microbiol. 2012 May 20;12:79. doi: 10.1186/1471-2180-12-79. 2012.

Dutta NK, Mehra S, Martinez AN, Alvarez X, Renner NA, Morici LA, Pahar B, Maclean AG, Lackner AA, Kaushal D
The stress-response factor SigH modulates the interaction between Mycobacteriumtuberculosis and host phagocytes.
PLoS One. 2012;7(1):e28958. doi: 10.1371/journal.pone.0028958. Epub 2012 Jan 3. 2012.

Jensen K, Ranganathan UD, Van Rompay KK, Canfield DR, Khan I, Ravindran R, Luciw PA, Jacobs WR Jr, Fennelly G, Larsen MH, Abel K
A recombinant attenuated Mycobacterium tuberculosis vaccine strain is safe inimmunosuppressed simian immunodeficiency virus-infected infant macaques.
Clin Vaccine Immunol. 2012 Aug;19(8):1170-81. doi: 10.1128/CVI.00184-12. Epub2012 Jun 13. 2012.

Kaushal D, Mehra S, Didier PJ, Lackner AA
The non-human primate model of tuberculosis.
J Med Primatol. 2012 Jun;41(3):191-201. doi: 10.1111/j.1600-0684.2012.00536.x.Epub 2012 Mar 20. 2012.

Kaushal D, Mehra S
Faithful Experimental Models of Human Mycobacterium Tuberculosis Infection.
Mycobact Dis. 2012 Feb 20;2. doi: 10.4172/2161-1068.1000e108. 2012.

Kaushal D
Eicosanoids, prostaglandins, and the progression of tuberculosis.
J Infect Dis. 2012 Dec 15;206(12):1803-5. doi: 10.1093/infdis/jis611. Epub 2012Oct 2. 2012.

Mehra S, Golden NA, Stuckey K, Didier PJ, Doyle LA, Russell-Lodrigue KE, Sugimoto C, Hasegawa A, Sivasubramani SK, Roy CJ, Alvarez X, Kuroda MJ, Blanchard JL, Lackner AA, Kaushal D
The Mycobacterium tuberculosis stress response factor SigH is required forbacterial burden as well as immunopathology in primate lungs.
J Infect Dis. 2012 Apr 15;205(8):1203-13. doi: 10.1093/infdis/jis102. Epub 2012Mar 7. 2012.

Roy CJ, Sivasubramani SK, Dutta NK, Mehra S, Golden NA, Killeen S, Talton JD, Hammoud BE, Didier PJ, Kaushal D
Aerosolized gentamicin reduces the burden of tuberculosis in a murine model.
Antimicrob Agents Chemother. 2012 Feb;56(2):883-6. doi: 10.1128/AAC.05633-11.Epub 2011 Dec 5. 2012.

Weigler BJ, Cooper DR, Hankenson FC
Risk-based immunization policies and tuberculosis screening practices for animal care and research workers in the United States: survey results and recommendations.
J Am Assoc Lab Anim Sci. 2012;51(5):561-73. 2012.

2011

Day CL, Abrahams DA, Lerumo L, Janse van Rensburg E, Stone L, O'rie T, Pienaar B, de Kock M, Kaplan G, Mahomed H, Dheda K, Hanekom WA
Functional capacity of Mycobacterium tuberculosis-specific T cell responses inhumans is associated with mycobacterial load.
J Immunol. 2011 Sep 1;187(5):2222-32. doi: 10.4049/jimmunol.1101122. Epub 2011Jul 20. 2011.

Kasmar AG, van Rhijn I, Cheng TY, Turner M, Seshadri C, Schiefner A, Kalathur RC, Annand JW, de Jong A, Shires J, Leon L, Brenner M, Wilson IA, Altman JD, Moody DB
CD1b tetramers bind alphabeta T cell receptors to identify a mycobacterialglycolipid-reactive T cell repertoire in humans.
J Exp Med. 2011 Aug 29;208(9):1741-7. doi: 10.1084/jem.20110665. Epub 2011 Aug 1. 2011.

Luciw PA, Oslund KL, Yang XW, Adamson L, Ravindran R, Canfield DR, Tarara R, Hirst L, Christensen M, Lerche NW, Offenstein H, Lewinsohn D, Ventimiglia F, Brignolo L, Wisner ER, Hyde DM
Stereological analysis of bacterial load and lung lesions in nonhuman primates(rhesus macaques) experimentally infected with Mycobacterium tuberculosis.
Am J Physiol Lung Cell Mol Physiol. 2011 Nov;301(5):L731-8. doi:10.1152/ajplung.00120.2011. Epub 2011 Aug 26. 2011.

Madan-Lala R, Peixoto KV, Re F, Rengarajan J
Mycobacterium tuberculosis Hip1 dampens macrophage proinflammatory responses bylimiting toll-like receptor 2 activation.
Infect Immun. 2011 Dec;79(12):4828-38. doi: 10.1128/IAI.05574-11. Epub 2011 Sep26. 2011.

Mehra S, Golden NA, Dutta NK, Midkiff CC, Alvarez X, Doyle LA, Asher M, Russell-Lodrigue K, Monjure C, Roy CJ, Blanchard JL, Didier PJ, Veazey RS, Lackner AA, Kaushal D
Reactivation of latent tuberculosis in rhesus macaques by coinfection with simianimmunodeficiency virus.
J Med Primatol. 2011 Aug;40(4):233-43. doi: 10.1111/j.1600-0684.2011.00485.x. 2011.

Roy CJ, Ault A, Sivasubramani SK, Gorres JP, Wei CJ, Andersen H, Gall J, Roederer M, Rao SS
Aerosolized adenovirus-vectored vaccine as an alternative vaccine deliverymethod.
Respir Res. 2011 Nov 21;12:153. doi: 10.1186/1465-9921-12-153. 2011.

Stockinger DE, Roellich KM, Vogel KW, Eiffert KL, Torrence AE, Prentice JL, Stephens KG, Wallis CK, Hotchkiss CE, Murnane RD
Primary hepatic Mycobacterium tuberculosis complex infection with terminaldissemination in a pig-tailed macaque (Macaca nemestrina).
J Am Assoc Lab Anim Sci. 2011 Mar;50(2):258-62. 2011.

Wachtman LM, Miller AD, Xia D, Curran EH, Mansfield KG
Colonization with nontuberculous mycobacteria is associated with positivetuberculin skin test reactions in the common marmoset (Callithrix jacchus).
Comp Med. 2011 Jun;61(3):278-84. 2011.