Breakthrough Discoveries from the Oregon National Primate Research Center

Infectious Diseases

Hansen SG, Piatak M Jr, Ventura AB, Hughes CM, Gilbride RM, Ford JC, Oswald K, Shoemaker R, Li Y, Lewis MS, Gilliam AN, Xu G, Whizin N, Burwitz BJ, Planer SL, Turner JM, Legasse AW, Axthelm MK, Nelson JA, Früh K, Sacha JB, Estes JD, Keele BF, Edlefsen PT, Lifson JD, Picker LJ.
Immune clearance of highly pathogenic SIV infection.
Nature. 2013 Oct 3;502(7469):100-4. doi: 10.1038/nature12519. Epub 2013 Sep 11.

Fukazawa Y, Lum R, Okoye AA, Park H, Matsuda K, Bae JY, Hagen SI, Shoemaker R, Deleage C, Lucero C, Morcock D, Swanson T, Legasse AW, Axthelm MK, Hesselgesser J, Geleziunas R, Hirsch VM, Edlefsen PT, Piatak M Jr, Estes JD, Lifson JD, Picker LJ.
B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers.
Nat Med. 2015 Feb;21(2):132-9. doi: 10.1038/nm.3781. PMCID:PMC4320022 DOI:10.1038/nm.3781

Hessell AJ, Jaworski JP, Epson E, Matsuda K, Pandey S, Kahl C, Reed J, Sutton WF, Hammond KB, Cheever TA, Barnette PT, Legasse AW, Planer S, Stanton JJ, Pegu A, Chen X, Wang K, Siess D, Burke D, Park BS, Axthelm MK, Lewis A, Hirsch VM, Graham BS, Mascola JR, Sacha JB, Haigwood NL
Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques.
Nat Med. 2016 Apr;22(4):362-8. doi: 10.1038/nm.4063. Epub 2016 Mar 21.PMID:26998834; PMCID:PMC4983100; DOI:10.1038/nm.4063

Reproductive and Developmental Sciences

Tachibana M, Sparman M, Sritanaudomchai H, Ma H, Clepper L, Woodward J, Li Y, Ramsey C, Kolotushkina O, Mitalipov S.
Mitochondrial gene replacement in primate offspring and embryonic stem cells.
Nature. 2009 Sep 17;461(7262):367-72. doi: 10.1038/nature08368. Erratum in: Nature. 2014 Dec;516(7530):276.

This work led to the human subject work in the following:
Ma H, Folmes CD, Wu J, Morey R, Mora-Castilla S, Ocampo A, Ma L, Poulton J, Wang X, Ahmed R, Kang E, Lee Y, Hayama T, Li Y, Van Dyken C, Gutierrez NM, Tippner-Hedges R, Koski A, Mitalipov N, Amato P, Wolf DP, Huang T, Terzic A, Laurent LC, Izpisua Belmonte JC, Mitalipov S.
Metabolic rescue in pluripotent cells from patients with mtDNA disease.
Nature. 2015 Aug 13;524(7564):234-8. doi: 10.1038/nature14546. Epub 2015 Jul 15. PMID:26176921 DOI:10.1038/nature14546

Neuroscience

McBride JL, Clark RL.
Stereotaxic Surgical Targeting of the Nonhuman Primate Caudate and Putamen: Gene Therapy for Huntington's Disease.
Methods Mol Biol. 2016;1382:409-28. doi: 10.1007/978-1-4939-3271-9_29. PMID:26611603

Kohama SG, Renner L, Landauer N, Weiss AR, Urbanski HF, Park B, Voytko ML, Neuringer M.
Effect of Ovarian Hormone Therapy on Cognition in the Aged Female Rhesus Macaque.
J Neurosci. 2016 Oct 5;36(40):10416-10424. PMID: 27707975

Grayson DS, Kroenke CD, Neuringer M, Fair DA.
Dietary omega-3 fatty acids modulate large-scale systems organization in the rhesus macaque brain.
J Neurosci. 2014 Feb 5;34(6):2065-74. doi: 10.1523/JNEUROSCI.3038-13.2014. PMID: 24501348

Metabolic Disorders

Kievit P, Halem H, Marks DL, Dong JZ, Glavas MM, Sinnayah P, Pranger L, Cowley MA, Grove KL, Culler MD.
Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces insulin resistance, and improves cardiovascular function in diet-induced obese rhesus macaques.
Diabetes. 2013 Feb;62(2):490-7. doi: 10.2337/db12-0598. PubMed PMID: 23048186; PubMed Central PMCID: PMC3554387.

Shin AC, Fasshauer M, Filatova N, Grundell LA, Zielinski E, Zhou JY, Scherer T, Lindtner C, White PJ, Lapworth AL, Ilkayeva O, Knippschild U, Wolf AM, Scheja L, Grove KL, Smith RD, Qian WJ, Lynch CJ, Newgard CB, Buettner C.
Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism.
Cell Metab. 2014 Nov 4;20(5):898-909. doi: 10.1016/j.cmet.2014.09.003. PubMed PMID: 25307860; PubMed Central PMCID: PMC4254305.

Genetics

Cervera-Juanes R, Wilhelm LJ, Park B, Grant KA, Ferguson B.
Alcohol-dose-dependent DNA methylation and expression in the nucleus accumbens identifies coordinated regulation of synaptic genes.
Transl Psychiatry. 2017 Jan 10;7(1):e994. doi: 10.1038/tp.2016.266. PubMed PMID: 28072409.