Nonhuman Primate Model Citations

Natural Disease Models

Monogenic- gene reported	Scientific Area	Associated Gene	Species affected	Citations	PMID:
Achromatopsia	Vision	PDE6C	Rhesus macaque	Moshiri et al., 2019	30667376
Bardet Biedl syndrome	Vision, nephrology	BBS7	Rhesus macaque	Peterson et al., 2019	31589838
Batten disease	Neurodegenerative	CLN7	Japanese macaque	McBride et al., 2018	30048804
Krabbe disease	Neurodegenerative	GALC	Rhesus macaque	Luzi, et al., 1997 Baskin et al., 1998	9192853 10090061
Epidermolysis Bullosa Simplex	Dermotology	KRT5	Rhesus macaque	Johnson et al., 2019	32096448
Complex - gene reported	Scientific Area	Associated Gene	Species affected	Citations	PMID:
Age-related macular degeneration	Vision	HTRA1, ARMS2	Rhesus macaque	Francis, et al., 2008 Singh, et al., 2009	18535016 19028492
HPA axis dysregulation	Neuroscience	TPH2, MAOA, OPRM1	Rhesus macaque	Chen et al., 2006 Chen et al., 2010 Ferguson, et al., 2012	16847459 19900455 21459516 22998353
Alcohol use disorder	Neuroscience	OPRM1, CRH, MAOA	Rhesus macaque	Lindell, et al., 2010 Barr, et al., 2009 Cervera-Juanes, et al., 2016	15652876 15251892 26148813
Naltrexone response	Neuroscience/drug response	OPRM1	Rhesus macaque	Barr et al., 2010 Vallender et al., 2010	19748082 20153935
Anxiety	Neuroscience/psychiatric	CRHR1, SLC6A4	Rhesus macaque	Spinelli, et al., 2012 Rogers, et al., 2013 Kalin et al., 2008	22293001 23147386 18414408
SIV/SHIV progression	Immunology/infectious disease	TRIM5	Rhesus macaque	Letvin, et al., 2011 Lim, et al., 2010	21543722 20585621 20107597
SIV/SHIV progression	Immunology/infectious disease	TLR4	Sooty mangabey	Palesch D et al., 2018	29300007
Amenorrhea	Reproductive biology	EAP1	Rhesus macaque	Lomniczi, et al., 2012	22128021
Obesity-CVD risk	Cardiovascular disease	TNF	Vervet	Gray et al., 2011	21331060
Colorectal cancer	Cancer	MLH1	Rhesus macaque	Brammer, et al., 2018 Dray et al., 2018	29490919 30108684
Gene association not reported	Scientific Area	Associated Gene	Species affected	Citations	PMID:
Left ventricular hypertrophy	Cardiovascular disease		Rhesus macaque	Reader, et al., 2016 Ueda Y, et al., 2019	27053572 27538864 30723724
Coats-like retinopathy	Vision		Rhesus macaque	Liu, et al., 2015	25656754
Multiple sclerosis	Neurodegenerative		Japanese macaque	Axthelm et al., 2011	21674589
Autism	Psychiatric/neuroscience		Rhesus macaque	Bauman et al., 2018 Capitanio, 2017 Thompson et al., 2018	28774750 28472500 29740395
Epilepsy	Neuroscience		Baboon	Szabo et al., 2018 Salinas and Szabo, 2015	26290449 31592545
Osteoporosis	Aging		Rhesus macaque	Simmons, et al., 2016 Coleman, 2018 Paschalis et al., 2019	26864889 28729086 30414509
Polycystic ovary syndrome (PCOS)	Reproductive biology		Rhesus macaque	Abbott, et al., 2017, 2019	28333238 31783681
Endometriosis	Reproductive biology		Rhesus macaque, Baboon	Assaf, et al., 2012 Keator et al., 2012 D'Hooghe et al., 2009 Nair et al., 2016	21521902 22307145 19208783 26908459
Alzheimer's disease	Neurodegeneration		Rhesus macaque	Paspalas, et al., 2018 Cramer et al., 2018	29241829 29353102
Squamous cell carcinoma	Cancer		Rhesus macaque, Pigtail macaque	Jean, et al., 2011 Stockinger et al., 2014	24956217
Behavioral anxiety	Neuroscience		Rhesus macaque	Morin et al., 2019 Ramsey et al., 2018 Kinnally et al., 2018	31170549 30450801 30103289

Selected Induced Disease Models

Induced Disease Model	Scientific Area	Species affected	Citations	PMID:
Ebola virus	Infectious disease	Rhesus and cynomolgus macaques	Zeng et al., 2017 Geisbert et al., 2015 Warren et al., 2016 Martins et al., 2015	28715405 26063223 26934220 25514385
Zika virus	Infectious disease	Rhesus, pigtail macaque, baboon	Adams Waldorf et al., 2016 Steinbach et al., 2019 Moreno et al., 2020 Peregrine et al., 2019 Dudley et al., 2018;	31935257 31801867 31597777 29967348 27618651
Sexually-transmitted diseases	Infectious disease	Pigtail macaque	Bell et al., 2011 Patton et al., 2018 Henning et al., 2017	21869858 29463617 28488731
Alzheimer's disease	Neurodegeneration	Rhesus macaque	Conner, Darracq, Roberts, Tuszynski, 2001 Beckman et al., 2019 Hara, Waters, McEwen, Morrison, 2015	11172055 30204256 26109339
Parkinson’s disease	Neurodegeneration	Rhesus macaque	Potts et al., 2014 Masilamoni and Smith, 2018	24070854 28861737
Diet-induced metabolic disease	Cardiovascular disease	Rhesus macaque	Butler et al., 2020 Bremmer et al., 2011 Stanhope and Havel, 2008 Mustafa et al., 2019 Wesolowski et al., 2018 Kuo et al., 2019	21613559 30947272 30337225 31180495
Alcohol use disorder	Addiction	Rhesus and cynomolgus macaques	Baker et al., 2014 Grant et al., 2008 Allen et al., 2018	25421519 18702645 29051997
Osteoporosis (ovariectomy-induced)	Bone health	Rhesus and cynomolgus macaques	Jerome CP, Peterson, 2001 Kahler-Quesada et al., 2019 Purnell et al., 2017	25421519 31557335 30753523
Obstetric complications	Womens health	Pigtail macaque	Jocobson et al., 2011 Adams Waldorf et al., 2015	21659720 26284599